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|Family Medicine (FM)/General Practice (GP)|
|General Internal Medicine-Primary Care(US)|
An important evidence-based update on the management of hypercholesterolemia!
Very detailed analysis and suggestions with more summary take-home messages that should be useful.
A useful and practical guide concentrating appropriately on the use of statins and their side effects. The CV risk threshold for statin introduction remains 7.5%. Quite a lot of the suggestions made are labelled as 'reasonable' - presumably meaning that the evidence is inconclusive. PCSK9 inhibitors (not available in my country) are still too expensive to win a recommendation. The evidence supporting greater use of coronary calcium studies is not clear.
This is the full set of guidelines for treating cholesterol that was published in August 2018 and is > 60 pages long. Pros: It is organized by patient risk category, it has all the evidence in one place, and it`s endorsed by just about every group out here. Cons: it is quite long and it may take a minute to locate the answer you want. Still, probably everyone should have this article bookmarked.
There was a synopsis of this in the Annals of Internal Medicine last month.
Guidelines are usually highly clinically relevant. This guideline is no exception given the broad-reaching topic and highly reputable sponsoring societies.